Computational Methods for Three-Dimensional Electron Microscopy (3DEM)

in Special Issue   Posted on April 26, 2021 

Information for the Special Issue

Submission Deadline: Wed 15 Dec 2021
Journal Impact Factor : 3.632
Journal Name : Computer Methods and Programs in Biomedicine
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Website for the Special Issue:
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Special Issue Call for Papers:

Call for paper – Computer Methods and Programs in Biomedicine

Computational Methods for Three-Dimensional Electron Microscopy (3DEM)

Short title: 3DEM

Recent revolutionary advancements have established three-dimensional electron microscopy (3DEM) as an essential structural tool for the research into tissues, cells, organelles and proteins in the context of biomedical studies. The 3DEM modalities cover different sample volumes and length scales that make them specific for the target investigation. Single particle cryo-EM, awarded with 2017 Nobel Prize in Chemistry, allows 3D structure determination of isolated proteins and macromolecules of biomedical relevance at (near-)atomic resolution and has exciting potential for facilitating drug design. Cryo-electron tomography (cryo-ET) enables in situ 3D visualization of the macromolecules and their interactions in their unperturbed cellular environment at close-to-nanometer resolution. Electron tomography (ET) facilitates the 3D structural analysis of tissues, cells and organelles at a resolution of a few nanometers from samples sub-half-micron thick. Last but not least, the modalities collectively known as Large Volume EM (e.g. SBF/SEM, FIB/SEM, cryo-FIB/SEM) allow ultrastructural analysis of cells and tissues in their native spatial context with unlimited thickness and at an unprecedented nanoscale detail, which make them exceedingly beneficial for biomedical research. Furthermore, these 3DEM techniques can be combined through multiscale integrative/correlative approaches so as to enable a comprehensive description of the ultrastructure and the alterations under pathological conditions.

The computational methods constitute an essential component of these imaging techniques and have played a major role in the current position of 3DEM. Future developments are expected to have a profound impact in tackling the current challenges and further promoting the application of 3DEM to biomedicine and health research.

Computer Methods and Programs in Biomedicine is a well-established Computer Science journal that welcomes new computing methods applied to biomedicine and intends to serve from biologists and biochemists to engineers and computer scientists.

This special issue on 3DEM aims to present computational innovations that will contribute to the advancement of the 3DEM modalities and their application to biomedical research. Invited authors are encouraged to submit manuscripts describing computer methods on topics related to image processing, 3D reconstruction, extraction of information, quantitative interpretation and multiscale/correlative integration.

Publication Schedule

Portal opens: 15 May 2021

Submission deadline: 15 December 2021

Peer-review process: June 2021 – February 2022

Revised manuscript due + Final acceptance: September 2021-Abril 2022

Special Issue Guest Editors

Dr. José-Jesús Fernández

Spanish National Research Council (CSIC, CINN), Health Research Institute of Asturias (ISPA), Oviedo, Spain.

Email: [email protected]

Dr. Antonio Martínez-Sánchez

University of Oviedo, Dept. Computer Science. Oviedo, Spain.

Email: [email protected]

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